Typhoid fever

  • A systemic infection caused by the gram-negative bacterium Salmonella enterica, subspecies enterica, serotype typhi
  • Following ingestion of contaminated food or water, S. typhi penetrates the intestinal mucosa, replicates and enters the bloodstream
  • The severity of symptoms varies. Clinical features range from mild fever, diarrhoea, myalgia and headache, to severe disseminated disease with multi-organ involvement in 10 to 15% of cases