A systemic infection caused by the gram-negative bacterium Salmonella enterica, subspecies enterica, serotype typhi
Following ingestion of contaminated food or water, S. typhi penetrates the intestinal mucosa, replicates and enters the bloodstream
The severity of symptoms varies. Clinical features range from mild fever, diarrhoea, myalgia and headache, to severe disseminated disease with multi-organ involvement in 10 to 15% of cases
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